Variability in interval production is due to timing dependent deficits in Huntington’s disease
Identifieur interne : 000366 ( Main/Exploration ); précédent : 000365; suivant : 000367Variability in interval production is due to timing dependent deficits in Huntington’s disease
Auteurs : Ashwini K. Rao ; Karen S. Marder ; Jasim Uddin ; Brian C. RakitinSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- complications : Huntington Disease.
- etiology : Perceptual Disorders.
- genetics : Huntington Disease.
- physiology : Time Perception.
- Adult, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index.
Abstract
In Huntington’s disease (HD) increased variability is seen in performance of motor tasks that require implicit control of timing. We examined if timing variability was also evident in an explicit interval-timing task.
Sixty subjects (21 controls, 19 manifest HD and 20 pre-manifest HD) performed a single interval production task with three target intervals (1.1s, 2.2s, 3.3s). We analyzed accuracy (proportional error) and precision (standard deviation) across groups and intervals.
No differences were seen in accuracy across groups or intervals. Precision was significantly lower in manifest (p=0.0001) and pre-manifest HD (p=0.04) compared with controls. This was particularly true for pre-manifest subjects close to diagnosis (based on probability of diagnosis in five years). Precision was correlated with proximity to diagnosis (r2=0.3, p<0.01). To examine the source of reduced precision, we conducted linear regression of standard deviation with interval duration. Slope of the regression was significantly higher in manifest HD (p=0.02) and in pre-manifest HD close to diagnosis (p=0.04) compared with controls and pre-manifest participants far from diagnosis.
Timing precision is impaired before clinical diagnosis in Huntington’s disease. Slope analysis suggests that timing variability (decreased precision) was due to deficits in timing dependent processes. Our results provide additional support for the proposal that the basal ganglia are implicated in central timekeeping functions. Since the single interval production task was sensitive to deficits in pre-manifest HD, temporal precision may be a useful outcome measure in future clinical trials.
Url:
DOI: 10.1002/mds.25998
PubMed: 25154339
PubMed Central: 4188696
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Variability in interval production is due to timing dependent deficits in Huntington’s disease</title>
<author><name sortKey="Rao, Ashwini K" sort="Rao, Ashwini K" uniqKey="Rao A" first="Ashwini K." last="Rao">Ashwini K. Rao</name>
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<author><name sortKey="Rakitin, Brian C" sort="Rakitin, Brian C" uniqKey="Rakitin B" first="Brian C." last="Rakitin">Brian C. Rakitin</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Female</term>
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<term>Huntington Disease (complications)</term>
<term>Huntington Disease (genetics)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Perceptual Disorders (etiology)</term>
<term>Severity of Illness Index</term>
<term>Time Perception (physiology)</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term>
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<term>Female</term>
<term>Humans</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">In Huntington’s disease (HD) increased variability is seen in performance of motor tasks that require implicit control of timing. We examined if timing variability was also evident in an explicit interval-timing task.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Sixty subjects (21 controls, 19 manifest HD and 20 pre-manifest HD) performed a single interval production task with three target intervals (1.1s, 2.2s, 3.3s). We analyzed accuracy (proportional error) and precision (standard deviation) across groups and intervals.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">No differences were seen in accuracy across groups or intervals. Precision was significantly lower in manifest (p=0.0001) and pre-manifest HD (p=0.04) compared with controls. This was particularly true for pre-manifest subjects close to diagnosis (based on probability of diagnosis in five years). Precision was correlated with proximity to diagnosis (r<sup>2</sup>
=0.3, p<0.01). To examine the source of reduced precision, we conducted linear regression of standard deviation with interval duration. Slope of the regression was significantly higher in manifest HD (p=0.02) and in pre-manifest HD close to diagnosis (p=0.04) compared with controls and pre-manifest participants far from diagnosis.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Timing precision is impaired before clinical diagnosis in Huntington’s disease. Slope analysis suggests that timing variability (decreased precision) was due to deficits in timing dependent processes. Our results provide additional support for the proposal that the basal ganglia are implicated in central timekeeping functions. Since the single interval production task was sensitive to deficits in pre-manifest HD, temporal precision may be a useful outcome measure in future clinical trials.</p>
</sec>
</div>
</front>
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<name sortKey="Rakitin, Brian C" sort="Rakitin, Brian C" uniqKey="Rakitin B" first="Brian C." last="Rakitin">Brian C. Rakitin</name>
<name sortKey="Rao, Ashwini K" sort="Rao, Ashwini K" uniqKey="Rao A" first="Ashwini K." last="Rao">Ashwini K. Rao</name>
<name sortKey="Uddin, Jasim" sort="Uddin, Jasim" uniqKey="Uddin J" first="Jasim" last="Uddin">Jasim Uddin</name>
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